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Exchange 2010 mailbox database unresponsive

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Hi all

I have three exchange servers, one with the transport role, two with database roles (staff and students respectively). All servers are exchange 2010 RU5, on 2008R2. One of my database servers has an odd issue. Twice in the last week, the database it hosts has become unresponsive at around mid-morning. No-one can connect via outlook or webmail, and the following (and pretty much only) error is recorded in the application log:

There are 10 RPC requests for the database "/o=College/ou=Exchange Administrative Group (FYDIBOHF23SPDLT)/cn=Configuration/cn=Servers/cn=SERVER/cn=Microsoft Private MDB" that have taken an abnormally long time to complete. This may be indicative of performance issues with your server.
All other errors relate to not being able to perform maintenance on the old databases that I've dismounted, but those are continual and appear not to be related in any way.

I've performed some maintenance on the server this week, namely the following:

- One the exchange server with issues, I moved ~100 mailboxes from an old database into the main database, and dismounted the old database as it no longer has any mailboxes in it. During this process, I temporarily ran out of space on the LUN that hosts the database logs. I increased the LUN size, and remounted the database successfully.
- Set up a temporary fourth exchange server to host some mailboxes (~2000) moved from a database that's hosted on the second mailbox server (the one without issues).

A reboot resolves the issue for at least the rest of the day, but nothing in the application log appears to help me to determine what caused the issue. The server has been fine up until this week, and it's unlikely a load problem as we're in the middle of the easter holidays, so it should be under less load than usual.

The only KB I can find online that even remotely relates to my issue is the following: High version bucket on the Exchange Server 2010 mailbox server but I'm receviing event log 10026, not 10027, and it seems that I can't download that patch without contacting Microsoft.

Has anyone seen this issue before?

Thanks

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